{"id":18366,"date":"2017-06-13T13:28:37","date_gmt":"2017-06-13T11:28:37","guid":{"rendered":"http:\/\/aktuelles.uni-frankfurt.de\/?p=18366"},"modified":"2023-02-23T16:17:13","modified_gmt":"2023-02-23T15:17:13","slug":"why-does-an-anesthetic-make-us-lose-consciousness","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/why-does-an-anesthetic-make-us-lose-consciousness\/","title":{"rendered":"Why does an anesthetic make us lose consciousness?"},"content":{"rendered":"<figure class=\"wp-block-image alignleft is-resized\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2017\/06\/beitragsbild_narkose-bewusstsein.jpg\" alt=\"\" class=\"wp-image-17822\" width=\"364\" height=\"252\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2017\/06\/beitragsbild_narkose-bewusstsein.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2017\/06\/beitragsbild_narkose-bewusstsein-300x208.jpg 300w\" sizes=\"(max-width: 364px) 100vw, 364px\" \/><\/figure>\n\n\n\n<p><em><strong>Anesthetics cause certain areas of the brain to generate less information.<\/strong><\/em><\/p>\n\n\n\n<p>To date, researchers assumed that anesthetics interrupt signal transmission between different areas of the brain and that is why we lose consciousness. Neuroscientists at Goethe University Frankfurt and the Max Planck Institute for Dynamics and Self-Organization in G\u00f6ttingen have now discovered that certain areas of the brain generate less information when under anesthesia. The drop in information transfer often measured when the brain is under anesthesia could be a consequence of this reduced local information generation and not \u2013 as was so far assumed \u2013 a result of disrupted signal transmission between brain areas.<\/p>\n\n\n\n<p>If only a few telephone calls are made in a city then it could be the case that several telecommunication systems have broken down \u2013 or it is nighttime and most people are asleep. The situation is similar in an anesthetized brain: if there is remarkably little information transfer between various areas of the brain then either signal transmission in the nerve fibers is blocked or certain areas of the brain are less active as far as the generation of information is concerned.<\/p>\n\n\n\n<p>Patricia Wollstadt, Favio Frohlich, their colleagues from the Brain Imaging Center at Goethe University Frankfurt and researchers at the MPI for Dynamics and Self-Organization have now investigated this second hypothesis. As they have announced in the current issue of \u201cPLOS Computational Biology\u201d, they used ferrets to examine \u201csource\u201d brain areas from which less information was transmitted under anesthesia than in a waking state. They found that information generation under anesthesia was far more affected there than in the \u201ctarget\u201d brain areas to which the information was transferred. This indicates that it is the information available in the source area which determines information transfer and not a disruption in signal transmission. Were the latter the case, a far greater reduction could be expected in the target areas since less information \u201carrives\u201d there.<\/p>\n\n\n\n<p>\u201cThe relevance of this alternative explanation goes beyond anesthesia research, says Patricia Wollstadt, \u201csince each and every examination of neuronal information transfer should categorically take into consideration how much information is available locally and is therefore also transferable.\u201d<\/p>\n\n\n<p><strong>Publication<\/strong>: Patricia Wollstadt, Kristin K. Sellers, Lucas Rudelt, Viola Priesemann, Axel Hutt, Flavio Fr\u00f6hlich, Michael Wibral: Breakdown of local information processing may underlie isoflurane anesthesia effects, in PLOS Computational Biology, <a href=\"http:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1005511\">http:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1005511<\/a><\/p>\n\n\n\n<p><em><strong>Source: <a href=\"http:\/\/www.goethe-university-frankfurt.de\/66934196\/019\">Press Release 13\/06\/17<\/a><\/strong><\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Anesthetics cause certain areas of the brain to generate less information. To date, researchers assumed that anesthetics interrupt signal transmission between different areas of the brain and that is why [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":17822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[247],"post_folder":[],"class_list":["post-18366","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-medicine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Why does an anesthetic make us lose consciousness? | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/why-does-an-anesthetic-make-us-lose-consciousness\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Why does an anesthetic make us lose consciousness? | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"Anesthetics cause certain areas of the brain to generate less information. 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