{"id":23362,"date":"2017-11-14T12:26:50","date_gmt":"2017-11-14T11:26:50","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=23362"},"modified":"2023-02-23T15:28:04","modified_gmt":"2023-02-23T14:28:04","slug":"publication-in-nature-how-cells-filter-status-updates","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/publication-in-nature-how-cells-filter-status-updates\/","title":{"rendered":"Publication in &#8222;Nature&#8220;: How cells filter status updates"},"content":{"rendered":"<figure class=\"wp-block-image alignleft is-resized wp-image-23101\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2017\/11\/beitragsbild_nature-publikation-zellen-status-updates.jpg\" alt=\"\" class=\"wp-image-23101\" width=\"383\" height=\"265\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2017\/11\/beitragsbild_nature-publikation-zellen-status-updates.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2017\/11\/beitragsbild_nature-publikation-zellen-status-updates-300x208.jpg 300w\" sizes=\"(max-width: 383px) 100vw, 383px\" \/><figcaption class=\"wp-element-caption\">Structure of the MHC-I peptide-loading complex in the membrane of the endoplasmic reticulum. Image: Arne M\u00f6ller (Max Planck Institute of Biophysics), Simon Trowitzsch and Robert Tamp\u00e9 (Goethe University Frankfurt)<\/figcaption><\/figure>\n\n\n\n<p>Social media have become an indispensable part of our everyday life. We use them constantly to screen the latest news and share pre-selected information. The cells in our body do a similar thing. Information is pre-selected and transmitted to the immune system in order to fight against unwelcome invaders, such as viruses, bacteria, parasites or cancer. This pre-selection occurs by means of a highly complex molecular machine. Biochemists at Goethe University Frankfurt and the Max Planck Institute of Biophysics, in cooperation with researchers at Martin Luther University Halle-Wittenberg, have now unveiled the inner workings of this complex molecular machine.<\/p>\n\n\n\n<p>Status updates of each cell are transmitted from the cell\u2019s interior to the immune system in the form of small protein fragments. These fragments are presented on the cell surface by specific proteins, known as MHC-I molecules. Cancerous or infected cells can thus be quickly identified and eliminated. However, viruses and tumours can also trick the immune system and in so doing escape immune surveillance. In addition, ambiguous messages can lead to autoimmune diseases or chronic inflammation.<\/p>\n\n\n\n<p>That is why it is particularly important to understand how this highly complex molecular machine in the cell\u2019s interior selects the relevant protein fragments and coordinates the loading of MHC-I molecules. In the current issue of the renowned scientific journal NATURE, the researchers from Frankfurt and Halle provide first insights into the molecular architecture and inner workings of what is referred to as the MHC-I peptide-loading complex.<\/p>\n\n\n\n<p>\u201cWe had to pull out all the stops to prepare this extremely fragile complex for structural analyses,\u201d explains Dr. Simon Trowitzsch of the Institute of Biochemistry at Goethe University Frankfurt. \u201cFirst of all, we expanded our biochemical toolbox and developed a viral molecular bait that allowed us to isolate the native MHC-I peptide-loading complex from the endoplasmic reticulum.\u201d<\/p>\n\n\n\n<p>\u201cThanks to groundbreaking advances in cryo-electron microscopy, which were recently awarded the Nobel Prize, we were able to look closely at the MHC-I peptide-loading complex &#8211; which is about a hundred thousand times smaller than a pinhead &#8211; and to determine its molecular structure,\u201d reports Dr. Arne M\u00f6ller from the Max Planck Institute of Biophysics.<\/p>\n\n\n\n<p>The scientists can now deduce how the cell manages to generate information important for the immune system. Its structure shows how transport proteins in the membrane, folding enzymes and MHC-I molecules are working together precisely within a highly dynamic complex.<\/p>\n\n\n\n<p>\u201cOur research shows how the MHC-I peptide-loading complex filters out only those fragments of information which are actually needed by the immune system\u2019s effector cells. These findings have solved a decades-old puzzle and allow us now to describe the antigen selection process with greater precision. This knowledge will help to further improve immunotherapies,\u201d concludes Professor Robert Tamp\u00e9 from the Institute of Biochemistry.<\/p>\n\n\n<p><strong>Publication:<\/strong> Andreas Blees, Dovil\u0117 Janulien\u0117, Tommy Hofmann, Nicole Koller, Carla Schmidt, Simon Trowitzsch, Arne Moeller &amp; Robert Tamp\u00e9: Structure of the human MHC-I peptide-loading complex, NATURE (Nov 6, 2017, First Release) doi:10.1038\/nature24627<\/p>\n\n\n\n<p><strong><em>Source:&nbsp;<a href=\"http:\/\/www.goethe-university-frankfurt.de\/69218724\/033\" target=\"_blank\" rel=\"noopener\">Press Release 14\/11\/17<\/a><\/em><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>Social media have become an indispensable part of our everyday life. We use them constantly to screen the latest news and share pre-selected information. The cells in our body do [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":23101,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[243],"post_folder":[],"class_list":["post-23362","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-biochemistry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publication in &quot;Nature&quot;: How cells filter status updates | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/publication-in-nature-how-cells-filter-status-updates\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publication in &quot;Nature&quot;: How cells filter status updates | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"Social media have become an indispensable part of our everyday life. 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