{"id":42281,"date":"2020-02-17T14:38:42","date_gmt":"2020-02-17T13:38:42","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=42281"},"modified":"2023-02-22T16:42:43","modified_gmt":"2023-02-22T15:42:43","slug":"proxidrugs-project-led-by-goethe-university-included-in-clusters4future-programme","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/proxidrugs-project-led-by-goethe-university-included-in-clusters4future-programme\/","title":{"rendered":"PROXIDRUGS project led by Goethe University included in \u201cClusters4Future\u201d programme"},"content":{"rendered":"<p>PROXIDRUGS, the regional network led by Goethe University, aims at developing active molecules for selective intervention, opening new therapeutic avenues. Within the \u201cClusters4Future\u201d ideas competition, the Federal Ministry of Education and Research has now selected the project for funding in the concept phase \u2013 as one of 16 finalists out of 137 proposals submitted.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2020\/02\/Proxidrugs_klein.jpg\" alt=\"\" class=\"wp-image-42289\" width=\"650\" height=\"450\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2020\/02\/Proxidrugs_klein.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2020\/02\/Proxidrugs_klein-300x208.jpg 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption><em>Diagram of PROTACs\u2019 mode of action. A PROTAC is bifunctional and comprises a ligand (L, green) for the enzyme E3 ligase and a binding domain (L, red) for the target protein, connected via a short linker region (black). (Graphik: IBC2\/GU)<\/em><\/figcaption><\/figure><\/div>\n\n\n\n<p>\u201cThe body has developed an ingenious\nmechanism for disposing of superfluous or harmful proteins. We wish to seize this\nto break down disease-relevant proteins,\u201d says PROXIDRUGS coordinator Professor\nIvan \u0110iki\u0107 from the Institute of Biochemistry II at Goethe University,\nexplaining the project\u2019s rationale. Developing better therapies for diseases\nsuch as cancer, &nbsp;heart or &nbsp;inflammatory disease is the goal of the\nalliance of biochemists, chemists, clinicians and pharmacists from Goethe\nUniversity, the Fraunhofer Institute for Molecular Biology and Applied Ecology\n(IME) and TU Darmstadt.<\/p>\n\n\n\n<p>The Federal Ministry of Education and\nResearch will support the project with funds of up to \u20ac 250,000 during the six-month concept\nphase starting in May. If the alliance then qualifies for the implementation\nphase, up to \u20ac 5 million will be available per year for PROXIDRUGS. With\nthis funding scheme, the Ministry wants to turn scientific hotspots into\npowerful regional innovation networks. \u201cGoethe University at the heart of the\nRhine-Main region, a top location unique in Germany, bundles academic and\nindustrial expertise for the development of innovative therapeutic concepts,\u201d\nsays Professor Simone Fulda, the University\u2019s Vice-President, praising the\nconsortium\u2019s approach, which is based on reprogramming of the cell\u2019s own\nsystems.<\/p>\n\n\n\n<p>Proteins destined for degradation are\nusually marked in an enzymatic reaction with the small protein ubiquitin. The\ncell\u2019s \u201cshredder\u201d, the proteasome, recognizes this signal and breaks the respective\nprotein down into its individual components, which are then recycled. At the focus\nof PROXIDRUGS is a novel class of drugs acting through a proximity-based\nmechanism: The corresponding molecules exhibit two functional units \u2013 one for\nthe selective binding of the respective target protein and a second one to dock\nonto the required enzyme. In this way, any unwanted protein that has a suitable\nbinding pocket can in principle be marked with ubiquitin and flagged for\ndegradation.<\/p>\n\n\n\n<p>First molecules based on this principle,\ncalled PROTACs (<em>Proteolysis Targeting Chimeric Molecules<\/em>), already exist.\nA major advantage is their high specificity and catalytic mode of action \u2013\nmeaning that each molecule can carry out multiple reactions, such that only a\nsmall amount of active drug is needed. First trials with PROTACs in prostate\nand breast cancer are currently underway. The researchers in the PROXIDRUGS\nalliance now want to create new molecules in this very promising class of\ndrugs, e.g. for &nbsp;diseases that until now cannot\nbe treated with small molecules.<\/p>\n\n\n\n<p>One of the aims of the PROXIDRUGS alliance\nof Goethe University, TU Darmstadt and the Fraunhofer IME is to bundle existing\nexpertise in basic and clinical research, in pharmaceutical and biotech\ncompanies in the Rhine-Main region within one network. \u201cTranslation of our\nresults to the clinic will be challenging,\u201d says \u0110iki\u0107. \u201cHowever, thanks to\nclose collaboration with regional companies, which have already shown great\ninterest in the project, and the involvement of University Hospital Frankfurt,\nI\u2019m confident that we\u2019ll master this challenge.\u201d<\/p>","protected":false},"excerpt":{"rendered":"<p>PROXIDRUGS, the regional network led by Goethe University, aims at developing active molecules for selective intervention, opening new therapeutic avenues. Within the \u201cClusters4Future\u201d ideas competition, the Federal Ministry of Education [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":42289,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[243,247],"post_folder":[],"class_list":["post-42281","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-biochemistry","tag-medicine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PROXIDRUGS project led by Goethe University included in \u201cClusters4Future\u201d programme | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/proxidrugs-project-led-by-goethe-university-included-in-clusters4future-programme\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PROXIDRUGS project led by Goethe University included in \u201cClusters4Future\u201d programme | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"PROXIDRUGS, the regional network led by Goethe University, aims at developing active molecules for selective intervention, opening new therapeutic avenues. 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Ein PROTAC ist bifunktional und besteht aus einem Liganden (L, gr\u00fcn) f\u00fcr das Enzym E3-Ligase und einer Bindedom\u00e4ne (L, rot) f\u00fcr das Zielprotein, verbunden \u00fcber eine kurze Linkerregion (schwarz). 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