{"id":44878,"date":"2020-06-22T14:07:19","date_gmt":"2020-06-22T12:07:19","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=44878"},"modified":"2023-02-22T15:53:59","modified_gmt":"2023-02-22T14:53:59","slug":"tsetse-flytraps-biotechnology-for-africas-rural-population","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/tsetse-flytraps-biotechnology-for-africas-rural-population\/","title":{"rendered":"Tsetse flytraps: Biotechnology for Africa\u2019s rural population"},"content":{"rendered":"<p>Because the tsetse fly can transmit sleeping sickness, it is commonly combatted with insecticides or caught in traps. Bioscientists at Goethe University have now developed a method for producing the attractants for the traps in a biotechnological procedure. The Frankfurt scientists hope that in the future, the attractants can then be produced locally in rural areas of Africa at low cost.<\/p>\n\n\n\n<p>The tsetse fly occurs in large regions of sub-Saharan\nAfrica. The flies feed on human and animal blood, transmitting trypanosoma in\nthe process \u2013 small, single-cell organisms that use the flies as intermediate\nhost and cause a dangerous inflammation of the lymph and nervous system in both\nanimals and humans. There is no vaccination for this sleeping sickness;\nuntreated, it usually ends in death. In agriculture, particularly cattle\nbreeding, sleeping sickness \u2013 or trypanosomiasis \u2013 causes enormous damages in\nthe form of sick and dead animals.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2020\/06\/Bild_Tsetsefliege.jpg\" alt=\"\" class=\"wp-image-44893\" width=\"243\" height=\"323\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2020\/06\/Bild_Tsetsefliege.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2020\/06\/Bild_Tsetsefliege-225x300.jpg 225w\" sizes=\"(max-width: 243px) 100vw, 243px\" \/><\/figure><\/div>\n\n\n\n<p>In addition to the use of insecticides,\nthe insects are also caught in traps. The attractants used include substances\nthat also occur in cattle urine and which attract tsetse flies. These\nsubstances (3-ethylphenol and 3-propylphenol, or 3-EP and 3-PP for short) are\nsynthesized out of oil derivatives or also extracts from cashew nut shells\nthrough chemical processes. However, both processes are complex and neither\npractical nor affordable for rural communities in Africa.<\/p>\n\n\n\n<p>In the LOEWE collaborative research\nproject MegaSyn, molecular biologists at Goethe University have now succeeded\nin producing 3-EP and 3-PP in genetically modified brewer\u2019s yeast (<em>Saccharomyces cerevisiae<\/em>). They used a\nyeast strain into which they had previously introduced a new metabolic pathway,\nand changed its sugar metabolism. This enabled the yeasts to produce similarly\nhigh concentrations of 3-EP and 3-PP as those which occur in cow urine.<\/p>\n\n\n\n<p>Doctoral student Julia Hitschler from the Institute\nfor Molecular Biosciences at Goethe University explains: \u201cOur yeasts could\nideally grow in Africa in nutrient solutions on the basis of plant waste\nproducts, food rests or fodder rests. This would make production of the\nattractant almost cost-free. We are currently looking for partners to help us test\nour yeasts locally and provide them to the local population.\u201d<\/p>\n\n\n\n<p>The potential for the new yeasts go beyond\nthe tsetse attractants, add Professor Eckhard Boles, who heads the project. In\nthe future, other substances that have been previously won through oil or coal\ncould be produced through the new yeasts: \u201cOur yeasts could be developed to\nproduce other alkylphenols besides 3-EP and 3-PP. These alkylphenols could be\nused for the production of lubricant additives or surface-active substances in\ncleaning agents.\u201d<\/p>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\"><strong>Publication: <\/strong>Julia Hitschler, Martin Grininger, Eckhard Boles: <strong>Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and 3-propylphenol by engineering precursor supply in yeast<\/strong>. Scientific Reports, <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1038\/s41598-020-66997-5\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41598-020-66997-5<\/a><\/p>\n\n\n\n<p><em>Source: press release from 22 June 2020<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Because the tsetse fly can transmit sleeping sickness, it is commonly combatted with insecticides or caught in traps. Bioscientists at Goethe University have now developed a method for producing the [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":44892,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[246],"post_folder":[],"class_list":["post-44878","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-biological-sciences"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Tsetse flytraps: Biotechnology for Africa\u2019s rural population | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/tsetse-flytraps-biotechnology-for-africas-rural-population\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tsetse flytraps: Biotechnology for Africa\u2019s rural population | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"Because the tsetse fly can transmit sleeping sickness, it is commonly combatted with insecticides or caught in traps. 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