{"id":59294,"date":"2022-06-02T20:02:00","date_gmt":"2022-06-02T18:02:00","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=59294"},"modified":"2023-02-17T12:54:07","modified_gmt":"2023-02-17T11:54:07","slug":"genetics-how-a-harmless-environmental-bacterium-became-the-dreaded-hospital-germ-acinetobacter-baumannii","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/genetics-how-a-harmless-environmental-bacterium-became-the-dreaded-hospital-germ-acinetobacter-baumannii\/","title":{"rendered":"Genetics: How a harmless environmental bacterium became the dreaded hospital germ Acinetobacter baumannii"},"content":{"rendered":"<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2022\/06\/beitragsbild_krankenhauskeim.gif\"><img fetchpriority=\"high\" decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2022\/06\/beitragsbild_krankenhauskeim.gif\" alt=\"\" class=\"wp-image-59292\"\/><\/a><figcaption>Hospital germs like Acinetobacter strains are particularly feared for their ability to form biofilms, a gel-like substance to protect them.<\/figcaption><\/figure>\n\n\n\n<p><strong>Hospital-acquired infections (HAIs) are often particularly difficult to treat because the pathogens have developed resistance to common antibiotics. The bacterium <em>Acinetobacter baumannii<\/em> is particularly dreaded in this respect, and research is seeking new therapeutic approaches to combat it. To look for suitable starting points, an international team led by bioinformaticians at Goethe University Frankfurt has compared thousands of genomes of pathogenic and harmless <em>Acinetobacter<\/em> strains. This has delivered clues about which properties might have made <em>A. baumannii<\/em> a successful pathogen \u2013 and how it might possibly be combated.<\/strong><\/p>\n\n\n\n<p>Each year, over 670,000 people in Europe fall ill through pathogenic bacteria that exhibit antibiotic resistance, and 33,000 die of the diseases they cause. Especially feared are pathogens that are resistant to several antibiotics at the same time. Among them is the bacterium <em>Acinetobacter baumannii<\/em>, which is today dreaded above all as a \u201chospital superbug\u201d: up to five percent of all hospital-acquired bacterial infections are caused by this germ alone.<\/p>\n\n\n\n<p><em>A. baumannii<\/em> is right at the top of a list of candidates for which, according to the World Health Organization (WHO), new therapies must be developed. This is because the pathogen \u2013 due to a flexible genome \u2013 easily acquires new antibiotic resistance. At the same time, infections are not only occurring more and more outside the hospital environment but also leading to increasingly severe progression. However, a prerequisite for the development of new therapeutic approaches is that we understand which properties make <em>A. baumannii<\/em> and its human pathogenic relatives, grouped in what is known as the <em>Acinetobacter calcoaceticus-baumannii<\/em> (ACB) complex, a pathogen.<\/p>\n\n\n\n<p>A team led by bioinformatician Professor Ingo Ebersberger from Goethe University Frankfurt\/ LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG) has now reached a milestone in this understanding. The team is composed of members of Research Unit 2251 of the German Research Foundation and other national and international partners, among them scientists of Washington University School of Medicine, St Louis, USA.<\/p>\n\n\n\n<p>For their analysis, the team made use of the fact that a large proportion of the members of the <em>Acinetobacter<\/em> genus are harmless environmental bacteria that live in water or on plants or animals. Thousands of complete genome sequences both of these as well as of pathogenic <em>Acinetobacter<\/em> strains are stored in publicly accessible databases.<\/p>\n\n\n\n<p>By comparing these genomes, the researchers were able to systematically filter out differences between the pathogenic and the harmless bacteria. Because the incidence of individual genes was not particularly conclusive, Ebersberger and his colleagues concentrated on gene clusters, that is, groups of neighbouring genes that have remained stable during evolution and might form a functional unit. \u201cOf these evolutionarily stable gene clusters, we identified 150 that are present in pathogenic <em>Acinetobacter <\/em>strains and rare or absent in their non-pathogenic relatives,\u201d says Ebersberger, summing up. \u201cIt is highly probable that these gene clusters benefit the pathogens\u2019 survival in the human host.\u201d<\/p>\n\n\n\n<p>Among the most important properties of pathogens is their ability to form protective biofilms and to efficiently absorb micronutrients such as iron and zinc. And indeed, the researchers discovered that the uptake systems in the ACB group were a reinforcement of the existing and evolutionary older uptake mechanism.<\/p>\n\n\n\n<p>Particularly exciting is the fact that the pathogens have evidently tapped a special source of energy: they can break down the carbohydrate kynurenine produced by humans, which as a messenger substance regulates the innate immune system. The bacteria apparently kill two birds with one stone in this way. On the one hand, breaking down kynurenine supplies them with energy, and on the other hand, they could possibly use it to deregulate the host\u2019s immune response.<\/p>\n\n\n\n<p>Ebersberger is convinced: \u201cOur work is a milestone in understanding what\u2019s different about pathogenic <em>Acinetobacter baumannii.<\/em> Our data are of such a high resolution that we can even look at the situation in individual strains. This knowledge can now be used to develop specific therapies against which, with all probability, resistance does not yet exist.\u201d<\/p>\n\n\n\n<p class=\"has-background\" style=\"background-color:#eeeeee\"><strong>Publication: <\/strong>Bardya Djahanschiri, Gisela Di Venanzio, Jesus S. Distel, Jennifer Breisch, Marius Alfred Dieckmann, Alexander Goesmann, Beate Averhoff, Stephan G\u00f6ttig, Gottfried Wilharm, Mario F. Feldman, Ingo Ebersberger:<strong> Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex.<\/strong> PLOS Genetics (2022) DOI: 10.1371\/journal.pgen.1010020 <a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010020\">https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010020<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Hospital-acquired infections (HAIs) are often particularly difficult to treat because the pathogens have developed resistance to common antibiotics. The bacterium Acinetobacter baumannii is particularly dreaded in this respect, and research [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":59292,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[246],"post_folder":[],"class_list":["post-59294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-biological-sciences"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genetics: How a harmless environmental bacterium became the dreaded hospital germ Acinetobacter baumannii | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/genetics-how-a-harmless-environmental-bacterium-became-the-dreaded-hospital-germ-acinetobacter-baumannii\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetics: How a harmless environmental bacterium became the dreaded hospital germ Acinetobacter baumannii | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"Hospital-acquired infections (HAIs) are often particularly difficult to treat because the pathogens have developed resistance to common antibiotics. 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