{"id":76985,"date":"2023-10-20T10:24:09","date_gmt":"2023-10-20T08:24:09","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=76985"},"modified":"2023-10-20T13:55:33","modified_gmt":"2023-10-20T11:55:33","slug":"friedrich-merz-visiting-fellowship-endowment-it-all-comes-down-to-the-packaging","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/friedrich-merz-visiting-fellowship-endowment-it-all-comes-down-to-the-packaging\/","title":{"rendered":"Friedrich Merz Visiting Fellowship Endowment \/ It all comes down to the packaging"},"content":{"rendered":"<p><strong>Orally, intravenously or as an ointment \u2013 how drugs reach their target is a determining factor in their therapeutic effect. Samir Mitragotri, an expert in this field, will visit Goethe University Frankfurt in November.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2023\/10\/04_Friedrich-Merz-Gastprofessur_650x450-jpg.webp\"><img fetchpriority=\"high\" decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2023\/10\/04_Friedrich-Merz-Gastprofessur_650x450-jpg.webp\" alt=\"\" class=\"wp-image-76717\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2023\/10\/04_Friedrich-Merz-Gastprofessur_650x450-jpg.webp 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2023\/10\/04_Friedrich-Merz-Gastprofessur_650x450-300x208.webp 300w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2023\/10\/04_Friedrich-Merz-Gastprofessur_650x450-18x12.webp 18w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/a><figcaption class=\"wp-element-caption\">Samir Mitragotri (Foto: Ian Barin, Creative Commons)<\/figcaption><\/figure>\n\n\n\n<p>Samir Mitragotri, the prominent Indian American researcher from Harvard University, USA, will come to Frankfurt for a week in November as part of the Friedrich Merz Visiting Fellowship Endowment. At Harvard, he heads a laboratory for drug delivery systems and biomaterials at the John A. Paulson School of Engineering and Applied Sciences and the Wyss Institute, which works at the interface between basic research and engineering. Professor Maike Windbergs from Goethe University Frankfurt\u2019s Institute for Pharmaceutical Technology is organizing the visiting professorship, and will accompany Mitragotri throughout his stay. \u201cWe have known each other for many years. He was very impressed by the visiting professorship format and accepted our invitation immediately.\u201d Apart from a scientific symposium with high-ranking participants, there will also be a lecture for students and a symposium for Frankfurt citizens.<\/p>\n\n\n\n<p>As part of the visiting professorship, Mitragotri will speak to an audience of experts about his main topic, drug delivery, i.e. the development of drug delivery systems that facilitate drug administration. In general terms, these are systems that deliver a drug to its target site in the human body in a certain form and via a specific route \u2013 and in such a way that it maximizes the drug\u2019s therapeutic effect. \u201cThese systems transport fragile biomolecules, for example proteins,\u201d Windbergs explains. \u201cThey have to be packaged in such a way that they arrive in the body in the form that is the most effective. Only then can they also have the desired therapeutic effect.\u201d Drugs taken orally as tablets are the simplest method. An alternative is the administration by means of an injection, for example into a vein, a muscle or under the skin, i.e. subcutaneously. Then there are topical types of medication that are neither swallowed nor injected, such as ointments, nose spray, gargles or eye drops.<\/p>\n\n\n\n<p>The aim of the Friedrich Merz Visiting Fellowship Endowment is to invite a \u201cparticularly distinguished scientist\u201d in the field of pharmacy or medicine to Goethe University Frankfurt. To Windbergs, Mitragotri is the ideal candidate. \u201cHe has developed very sophisticated delivery systems that center on overcoming the biological barriers of the human body, such as the intestinal barrier or the skin.\u201d For transdermal drug delivery, he has developed peptides and ionic liquids that penetrate the skin. \u201cBecause these are charged, it is easier for the active ingredients to enter the body through the skin,\u201d Windbergs explains. In this way, it is possible to treat psoriasis, for example, without having to inject the active ingredient siRNA \u2013 which stands for \u201csmall interfering RNA\u201d, i.e. short, double-stranded RNA fragments composed of 21 to 28 nucleotides. They can immobilize a target gene by destroying its RNA transcripts. Although injecting siRNA into the skin is effective, it is painful and only covers small areas. Thanks to ionic liquids, topical, i.e. external, siRNA administration is now possible. In addition to methods that overcome the body\u2019s biological barriers, another of Mitragotri\u2019s most important topics is synthetic carriers that are transported like \u201chitchhikers\u201d around the body on its own cells \u2013 red blood cells, macrophages or T cells. \u201cThis enables more targeted drug delivery,\u201d explains Windbergs.<\/p>\n\n\n\n<p>What does Maike Windbergs personally hope to gain from the visiting professorship? Firstly, that intensifying \u201cbilateral communication\u201d between Harvard and Frankfurt will bring fresh ideas. Furthermore, Mitragotri\u2019s visit could give the topic of drug delivery greater overall visibility. In the past, it has mostly been the discovery of new active ingredients that has attracted attention. Drug delivery, in contrast, tends to lead a shadowy existence. \u201cThe coronavirus pandemic led to some progress in this area. People realized that we need not only a good vaccine but also good packaging so that the vaccine arrives in the body in the right way.\u201d Now, she says, Mitragotri will help raise greater awareness for the topic.<\/p>\n\n\n\n<p class=\"has-text-align-right\"><em>Author: Andreas Lorenz-Meyer<\/em><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-background\" style=\"background-color:#eeeeee\">The <strong>Friedrich Merz Visiting Fellowship<\/strong> <strong>Endowment<\/strong> was established in December 1985 to mark what would have been the 100<sup>th<\/sup> birthday of Friedrich Merz, the company\u2019s founder. As one of the first members of the Senckenberg Society for Nature Research, he was closely associated with Frankfurt University and a promoter of science. The aim of the visiting professorship is to attract a particularly distinguished scientist in the field of pharmacy or medicine to Goethe University Frankfurt. First endowed in 1987, it has since been awarded annually, apart from two exceptions. The visiting professorship and the symposium, whose topics range from basic research to healthcare, offer researchers from higher education and industry an opportunity each year to exchange knowledge and work more closely together. <a href=\"https:\/\/www.uni-frankfurt.de\/Friedrich-Merz-Stiftungsgastprofessur\" target=\"_blank\" rel=\"noreferrer noopener\">www.uni-frankfurt.de\/Friedrich-Merz-Stiftungsgastprofessur<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Orally, intravenously or as an ointment \u2013 how drugs reach their target is a determining factor in their therapeutic effect. Samir Mitragotri, an expert in this field, will visit Goethe [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":76717,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,260],"tags":[247,318],"post_folder":[],"class_list":["post-76985","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-events","tag-medicine","tag-unireport-5-23"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Friedrich Merz Visiting Fellowship Endowment \/ It all comes down to the packaging | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/friedrich-merz-visiting-fellowship-endowment-it-all-comes-down-to-the-packaging\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Friedrich Merz Visiting Fellowship Endowment \/ It all comes down to the packaging | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"Orally, intravenously or as an ointment \u2013 how drugs reach their target is a determining factor in their therapeutic effect. 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