{"id":77801,"date":"2023-11-27T17:02:47","date_gmt":"2023-11-27T16:02:47","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=77801"},"modified":"2023-11-27T17:02:48","modified_gmt":"2023-11-27T16:02:48","slug":"oncology-fighting-leukemia-with-therapeutic-rna","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/oncology-fighting-leukemia-with-therapeutic-rna\/","title":{"rendered":"Oncology: Fighting leukemia with therapeutic RNA"},"content":{"rendered":"<p><strong>Each year, around 13,000 people in Germany are diagnosed with leukemia, of which up to half die from the disease despite intensive chemotherapy. Beyond that, therapies have severe side effects: In particular, they inhibit the formation of normal blood cells. In a preclinical study, a team from the Department of Pediatrics at Goethe University Frankfurt has tested a novel therapy based on a therapeutic RNA. Through the treatment, the laboratory animals survived significantly longer than their untreated counterparts. The hope now is that this leukemia-specific therapy will be able to support existing chemotherapies in the future.<\/strong><\/p>\n\n\n\n<p>Each year, about 13,000 people in Deutschland are diagnosed with leukemia, an umbrella term that encompasses various forms of blood cancer. Among those affected are also many children and adolescents under 15 years of age. A common and very aggressive form of leukemia in adults is acute myeloid leukemia (AML). In AML, blood cells in the early stages \u2013 the stem cells and the precursor cells that develop out of them \u2013 transform. AML is the second most common form of leukemia in children, accounting for around four percent of all malignant diseases in childhood and adolescence. Despite treatment with intensive chemotherapy, only between 20 and 50 percent survive the first five years after diagnosis and treatment; half or more relapse and die. Furthermore, these intensive therapies have severe side effects: In particular, they damage the stem cells that form new blood. There is therefore an urgent need to develop new therapies tailored specifically to AML.<\/p>\n\n\n\n<p>Researchers led by Professor Jan-Henning Klusmann from the Department of Pediatrics and Professor Dirk Heckl from the Institute for Experimental Pediatric Hematology and Oncology at Goethe University Frankfurt have now tested such a leukemia-specific therapy in animal experiments. They used a therapeutic RNA molecule packaged in lipid nanoparticles to treat animals with leukemia. \u201cBy packaging it in lipid nanoparticles, we have in principle applied the same technique that was used for COVID-19 immunization,\u201d explains Klusmann. \u201cThe lipid nanoparticles transport the therapeutic RNA into the blood cells.\u201d<\/p>\n\n\n\n<p>The therapeutic RNA miR-193b was already described in 2018 as having a protective effect against cancer. In healthy cells, miR-193b slows down signaling pathways that are only activated for cell proliferation and which the stem cell otherwise hardly uses. That is why miR-193b is referred to as a tumor suppressor. In AML cells, however, miR-193b is not present in sufficient amounts and therefore unable to fulfil its task as a tumor suppressor. \u201cScientists have been testing active substances for many years that act as inhibitors and intervene in these signaling pathways used by AML cells,\u201d says Heckl. \u201cThe problem is that such substances only ever attack one component, whereas miR-193b acts on all levels of the signaling pathway. This stops the division of the abnormal cells very efficiently and causes the leukemia cells to die off quickly.\u201d Another advantage of therapeutic RNAs is that they do not damage the stem cells of the hematopoietic system, unlike conventional chemotherapies, because they are not dependent on the suppressed signaling pathways.<\/p>\n\n\n\n<p>All the laboratory animals tolerated the treatment with the nanoparticles containing the active substance well, and the leukemia cells were successfully fought off, as Klusmann summarizes: \u201cWe were able to significantly extend survival time in all the animals we treated, and some were even cured.\u201d What is particularly encouraging is that miR-193b worked in all the AML subtypes tested: The scientists examined four different types of cancer cells in their trials, including one common in people with Down syndrome. \u201cIn the past, noncoding RNAs and their genes were regarded as junk DNA,\u201d explains Klusmann. \u201cNow we have developed a therapy based on this \u2018junk\u2019 that promises a new and very specific treatment option for myeloid leukemia.\u201d The hope is that this therapy can support chemotherapies in the future so that they do not have to be so intensive.<\/p>\n\n\n\n<p class=\"has-background\" style=\"background-color:#eeeeee\"><strong>Publication: <\/strong>Hasan Issa, Raj Bhayadia, Robert Winkler, Laura Elise Swart, Dirk Heckl, Jan-Henning Klusmann: <strong>Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias.<\/strong> Leukemia 37, 1583 (2023) https:\/\/doi.org\/10.1038\/s41375-023-01937-6<\/p>","protected":false},"excerpt":{"rendered":"<p>Each year, around 13,000 people in Germany are diagnosed with leukemia, of which up to half die from the disease despite intensive chemotherapy. Beyond that, therapies have severe side effects: [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":77799,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[247],"post_folder":[],"class_list":["post-77801","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-medicine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Oncology: Fighting leukemia with therapeutic RNA | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/oncology-fighting-leukemia-with-therapeutic-rna\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oncology: Fighting leukemia with therapeutic RNA | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"Each year, around 13,000 people in Germany are diagnosed with leukemia, of which up to half die from the disease despite intensive chemotherapy. 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