{"id":80181,"date":"2024-06-24T10:21:35","date_gmt":"2024-06-24T08:21:35","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=80181"},"modified":"2024-06-24T10:21:36","modified_gmt":"2024-06-24T08:21:36","slug":"researchers-goethe-university-franziska-matthaeus-bioinformatician","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/researchers-goethe-university-franziska-matthaeus-bioinformatician\/","title":{"rendered":"Researchers @Goethe University: Franziska Matth\u00e4us, bioinformatician"},"content":{"rendered":"
\"\"<\/figure>\n\n\n\n

When bioinformatician Franziska Matth\u00e4us says she and her partners \u2013 biologists in Edinburgh and mathematicians in Turin and Darmstadt \u2013 describe pattern formation processes in the skin of mouse embryos, it sounds like something from an ivory tower. However, when she adds that they are investigating the even distribution of hair follicles (from which hairs will later grow), because \u201cotherwise the mouse the embryo grows into would be bald on some parts of its body and have dense tufts of hair on others,\u201d \u2013 her talent for comprehensible, down-to-earth explanations becomes clear.<\/p>\n\n\n\n

Matth\u00e4us, a member of Goethe University Frankfurt\u2019s Faculty of Computer Science and Mathematics, is conducting research with undergraduate and doctoral students at the Frankfurt Institute of Advanced Studies (FIAS), meaning she and her team only carry out theoretical work. They model and simulate spatio-temporal processes in multicellular structures. \u201cOf course we\u2019re always in constant close contact with experimental partners,\u201d Matth\u00e4us emphasizes, pointing first of all to the Physical Biology Group at Goethe University, which uses powerful fluorescence microscopes to create three-dimensional images of beetle larvae at various stages of their development, for example. These images form the basis of the data Matth\u00e4us and her group use to develop computer models \u2013 which in turn are deployed, in cooperation with the experimental partners, in researching an insect\u2019s development.<\/p>\n\n\n\n

When she graduated from Berlin\u2019s Humboldt-Universit\u00e4t with a degree in biophysics, Matth\u00e4us already knew she was headed for a career in theoretical natural science. \u201cI was always fascinated by the fact that you can use computers and mathematics to understand processes,\u201d she says. \u201cDuring my student days, I noticed that I definitely prefer sitting at a computer, analyzing data and thinking about processes, rather than perform complicated measurements with large pieces of laboratory apparatus, working with a pipette, and collecting the data myself.\u201d<\/p>\n\n\n\n

Successful internship<\/h2>\n\n\n\n

Of course theoreticians also need at least some idea of how experimental researchers obtain their measurements and data, she continues, and tells the story of how, in her first job as a group leader in Heidelberg, she and her entire working group completed a regular laboratory internship for students at the German Cancer Research Center. \u201cWe were familiar with algebra and computer science, but of course we had no experience at all in the lab, and therefore took much longer to do our experiments than the students who had already done an internship.\u201d She adds, with a hint of pride: \u201cBut our measuring results were really good \u2013 probably because we took a very meticulous approach to the experiments, not having had any previous laboratory experience.\u201d<\/p>\n\n\n\n

As part of her computer-aided research, Matth\u00e4us not only cooperates with individual partners, but is also involved in one of Goethe University Frankfurt\u2019s larger research initiatives: the SCALE cluster, which celebrated an important successful step in the excellence competition run by the German Research Foundation (DFG) in February 2024. The project focuses on the \u201cdigital twin\u201d of a biological cell.<\/p>\n\n\n\n

In contrast to AI models, digital twins are based as far as possible on physical descriptions of all processes. This not only enables them to predict the behavior of a system, but also show which mechanisms play a role and how they do so. Modelling approaches like this are the core expertise of Matth\u00e4us\u2019 working group, although to date it has been restricted to the level of tissue. \u201cBut we\u2019re currently working intensively on concentrating more on structures in the cell\u2019s interior as well, and creating digital twins of individual cells with the SCALE team,\u201d Matth\u00e4us stresses.<\/p>\n\n\n\n

Intensive work for C3<\/sup>S<\/h2>\n\n\n\n

Matth\u00e4us also sees the work with models, data and AI as one of the future tasks for the Center for Critical Computational Studies (C3<\/sup>S). This multi-faculty institution at Goethe University Frankfurt was founded in April 2023 to develop, apply and critically question digital procedures in equal measure \u2013 no matter whether the researchers are looking at scientific technical phenomena, social impacts or cultural products. As the center\u2019s founding director teaching, Matth\u00e4us is intensively involved in working with C3<\/sup>S\u2019 entire founding board and the university\u2019s faculties, centers and initiatives, to determine how C3<\/sup>S can be integrated into Goethe University\u2019s teaching structures.<\/p>\n\n\n\n

Matth\u00e4us is predestined for this task because she herself is passionate about passing on her knowledge to students. She says she loves accompanying young people for a while on their learning path, and recalls with enthusiasm: \u201cDuring my time in Heidelberg the greatest thing was when I came across students I recognized from my basic lectures who later became members of working groups with which we were doing interdisciplinary work. Today I also meet some former students from my lectures who have become professors themselves.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/p>\n\n\n\n

Stefanie Hense
<\/em><\/p>","protected":false},"excerpt":{"rendered":"

When bioinformatician Franziska Matth\u00e4us says she and her partners \u2013 biologists in Edinburgh and mathematicians in Turin and Darmstadt \u2013 describe pattern formation processes in the skin of mouse embryos, 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