{"id":82486,"date":"2025-02-09T12:11:05","date_gmt":"2025-02-09T11:11:05","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=82486"},"modified":"2025-02-09T12:11:09","modified_gmt":"2025-02-09T11:11:09","slug":"blood-vessels-are-to-blame-why-obesity-leads-to-diabetes","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/","title":{"rendered":"Blood vessels are to blame: why obesity leads to diabetes"},"content":{"rendered":"

The majority of the approximately 6 million patients in Germany who suffer from type 2 diabetes are overweight. The effect of insulin is limited in them. For a long time, the cause of this insulin resistance was primarily sought in metabolically active organs. Scientists from Max Planck Institute for Heart and Lung Research in Bad Nauheim and Goethe University Frankfurt have now been able to show that the effects of insulin on the inner cell layer of blood vessels, the endothelium, are of great importance for insulin resistance in fatty tissue and muscles. The key molecule here is the hormone adrenomedullin. With this study, the researchers hope to have found the basis for a new therapeutic principle for type 2 diabetes. The aim is now to develop substances that specifically target the blood vessels.<\/strong><\/p>\n\n\n\n

\"\"
Around 90 percent of patients with type 2 diabetes are severely overweight, also known as obese.<\/figcaption><\/figure>\n\n\n\n

More than 400 million people worldwide suffer from type 2 diabetes, around 6 million of them in Germany. In nine out of ten patients, severe overweight, known as obesity, leads to diabetes. Type 2 diabetes is characterized by the fact that body cells no longer absorb enough glucose. As a result, the glucose level in the blood rises. Insulin loses its effect, at least in part, and this is referred to as insulin resistance.<\/p>\n\n\n\n

In order to clarify the cause of insulin resistance in obese patients, research has so far focused primarily on metabolic organs such as the liver, adipose tissue and skeletal muscles. Receptors for insulin are found in the cells of these organs. So far, however, no therapeutic approaches have been developed to eliminate insulin resistance.<\/p>\n\n\n\n

Stefan Offermanns, Director of the \u201cPharmacology\u201d Department at the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Professor at Goethe University in Frankfurt, and his team have now investigated the role of the innermost cell layer in blood vessels, the so-called endothelium, in the development of type 2 diabetes in connection with obesity.<\/p>\n\n\n\n

Although it has long been known that receptors for insulin are also present on endothelial cells, their importance in the development of diabetes has been underestimated until now. \u201cWhen insulin docks to its receptor on the endothelium and activates it, this leads to dilation of the blood vessels and improved permeability of the vessel wall for insulin. As a result, glucose and insulin can better pass from the blood into metabolically active organs such as the liver and muscles,\u201d explains Haaglim Cho, first author of the study. This has been known for some time.<\/p>\n\n\n\n

The study carried out by the Bad Nauheim researchers on mice has shown for the first time that this mechanism can be disrupted in the case of severe obesity. \u201cIn mice that became obese as a result of a particularly high-calorie diet, insulin resistance developed after some time,\u201d says Cho. \u201cWe were able to identify a reduced activity of the insulin receptors of the endothelium as the cause of this.\u201d The results suggest that insulin resistance in the vascular endothelium leads to a reduced insulin effect in the entire organism, as the two mechanisms mentioned above, via which insulin is transported from the blood to the metabolically active organs, are then impaired.<\/p>\n\n\n\n

\"\"
In healthy, normal-weight mice, insulin leads to increased blood flow to the muscles by activating its receptor on the inside of the blood vessels (the endothelium) (red coloring, figures on the left). As a result, insulin and glucose reach the muscle cells efficiently and insulin promotes the uptake of glucose into the muscle cells. This results in a decrease in blood glucose levels. In overweight diabetic mice (middle images), there is considerable insulin resistance in the vascular system, which means that insulin has hardly any effect on blood flow to the muscles. This insulin resistance in the vascular system is caused by increased adrenomedullin levels. If the adrenomedullin receptor is switched off in overweight, diabetic animals (figures on the right), adrenomedullin loses its effect and insulin resistance decreases significantly. Insulin can now – as in a healthy state – cause significantly increased muscle perfusion, which leads to an improved metabolic state with reduced blood glucose levels. Photos: MPI for Heart and Lung Research.<\/figcaption><\/figure>\n\n\n\n

But what is the cause of the development of insulin resistance on the endothelium? Further experiments led the scientists to the hormone adrenomedullin. It is released into the blood in overweight people, particularly from fat cells. \u201cIn overweight mice, we found an effect comparable to that in human patients, namely that the adrenomedullin level in the blood is significantly increased. Another protein, complement factor H, is also elevated in the blood of both mice and humans with obesity. Our study showed that both factors reinforce each other in their effect on the insulin receptor,\u201d explains Cho.<\/p>\n\n\n\n

The effect of increased concentrations of adrenomedullin and complement factor H in the blood on the insulin effect was shown in further studies on mice: both factors synergistically activate the receptor for adrenomedullin on the endothelium, thus increasing their effect. The activated adrenomedullin receptor in turn inhibits the insulin receptor particularly strongly. This reduces the insulin effect. \u201cWe were able to confirm this finding in healthy, normal-weight mice to which we administered adrenomedullin. This also resulted in insulin resistance,\u201d says Cho. Conversely, mice in which the production of adrenomedullin or the activation of the endothelial adrenomedullin receptor was temporarily prevented by genetic engineering showed a normal insulin metabolism, even when they were overweight.<\/p>\n\n\n\n

Stefan Offermanns categorizes the study results: \u201cOur data show the insulin effects in blood vessels and how important the effect of insulin on blood vessels is for the systemic insulin effects.\u201d Above all, the study reveals a mechanism according to which the systemic insulin resistance of type 2 diabetes triggered by obesity is essentially based on insulin resistance in the vascular system. Offermann explains: \u201cWe hope that the improved understanding of type 2 diabetes caused by obesity is a first step towards the development of new substances that can be used to treat type 2 diabetes.\u201d<\/p>\n\n\n\n

Publication<\/strong>: Haaglim Cho, Chien-Cheng Lai, R\u00e9my Bonnavion, Mohamad Wessam Alnouri, ShengPeng Wang, Kenneth Anthony Roquid, Haruya Kawase, Diana Campos, Min Chen, Lee S. Weinstein, Alfredo Mart\u00ednez, Mario Looso, Miloslav Sanda, Stefan Offermanns: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Science (2025) http:\/\/science.org\/doi\/10.1126\/science.adr4731<\/a><\/p>\n\n\n\n

Source: Max Planck Institute for Heart and Lung Research<\/a><\/em><\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

The majority of the approximately 6 million patients in Germany who suffer from type 2 diabetes are overweight. The effect of insulin is limited in them. For a long time, […]<\/p>\n","protected":false},"author":8,"featured_media":82485,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[247],"post_folder":[],"class_list":["post-82486","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-medicine"],"yoast_head":"\nBlood vessels are to blame: why obesity leads to diabetes | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blood vessels are to blame: why obesity leads to diabetes | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"The majority of the approximately 6 million patients in Germany who suffer from type 2 diabetes are overweight. The effect of insulin is limited in them. For a long time, […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/\" \/>\n<meta property=\"og:site_name\" content=\"Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-09T11:11:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-09T11:11:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/02\/beitragsbild_uebergewicht-diabetes.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"650\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"-\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"-\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/\"},\"author\":{\"name\":\"-\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#\\\/schema\\\/person\\\/8e55ea338fb65d1ce87a91565d1f1739\"},\"headline\":\"Blood vessels are to blame: why obesity leads to diabetes\",\"datePublished\":\"2025-02-09T11:11:05+00:00\",\"dateModified\":\"2025-02-09T11:11:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/\"},\"wordCount\":1065,\"publisher\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/beitragsbild_uebergewicht-diabetes.jpg\",\"keywords\":[\"Medicine\"],\"articleSection\":[\"English\",\"Research\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/\",\"url\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/\",\"name\":\"Blood vessels are to blame: why obesity leads to diabetes | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/beitragsbild_uebergewicht-diabetes.jpg\",\"datePublished\":\"2025-02-09T11:11:05+00:00\",\"dateModified\":\"2025-02-09T11:11:09+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/#primaryimage\",\"url\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/beitragsbild_uebergewicht-diabetes.jpg\",\"contentUrl\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/beitragsbild_uebergewicht-diabetes.jpg\",\"width\":650,\"height\":450,\"caption\":\"Bei rund 90 Prozent der Patient*innen mit Typ-2-Diabetes ist die Ursache ein starkes \u00dcbergewicht, auch als Adipositas bezeichnet.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/english\\\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Blood vessels are to blame: why obesity leads to diabetes\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#website\",\"url\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/\",\"name\":\"Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\",\"description\":\"Aktuelles aus der Goethe-Universit\u00e4t | Neues aus Forschung, Lehre, Studium\",\"publisher\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#organization\",\"name\":\"Goethe-Universit\u00e4t\",\"url\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/800px-Goethe-Logo.png\",\"contentUrl\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/800px-Goethe-Logo.png\",\"width\":800,\"height\":436,\"caption\":\"Goethe-Universit\u00e4t\"},\"image\":{\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/#\\\/schema\\\/person\\\/8e55ea338fb65d1ce87a91565d1f1739\",\"name\":\"-\",\"description\":\"Dieser Beitrag wurde von der Online-Redaktion ver\u00f6ffentlicht. Wenn der Beitrag von einem Gastautoren verfasst wurde, findet sich dieser Hinweis am Ende des jeweiligen Artikels.\",\"sameAs\":[\"http:\\\/\\\/aktuelles.uni-frankfurt.de\\\/autoren\"],\"url\":\"https:\\\/\\\/aktuelles.uni-frankfurt.de\\\/en\\\/author\\\/redaktion\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Blood vessels are to blame: why obesity leads to diabetes | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/","og_locale":"en_GB","og_type":"article","og_title":"Blood vessels are to blame: why obesity leads to diabetes | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt","og_description":"The majority of the approximately 6 million patients in Germany who suffer from type 2 diabetes are overweight. The effect of insulin is limited in them. For a long time, […]","og_url":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/","og_site_name":"Aktuelles aus der Goethe-Universit\u00e4t Frankfurt","article_published_time":"2025-02-09T11:11:05+00:00","article_modified_time":"2025-02-09T11:11:09+00:00","og_image":[{"width":650,"height":450,"url":"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/02\/beitragsbild_uebergewicht-diabetes.jpg","type":"image\/jpeg"}],"author":"-","twitter_card":"summary_large_image","twitter_misc":{"Written by":"-","Estimated reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/#article","isPartOf":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/"},"author":{"name":"-","@id":"https:\/\/aktuelles.uni-frankfurt.de\/#\/schema\/person\/8e55ea338fb65d1ce87a91565d1f1739"},"headline":"Blood vessels are to blame: why obesity leads to diabetes","datePublished":"2025-02-09T11:11:05+00:00","dateModified":"2025-02-09T11:11:09+00:00","mainEntityOfPage":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/"},"wordCount":1065,"publisher":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/#organization"},"image":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/#primaryimage"},"thumbnailUrl":"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/02\/beitragsbild_uebergewicht-diabetes.jpg","keywords":["Medicine"],"articleSection":["English","Research"],"inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/","url":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/","name":"Blood vessels are to blame: why obesity leads to diabetes | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt","isPartOf":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/#website"},"primaryImageOfPage":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/#primaryimage"},"image":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/#primaryimage"},"thumbnailUrl":"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/02\/beitragsbild_uebergewicht-diabetes.jpg","datePublished":"2025-02-09T11:11:05+00:00","dateModified":"2025-02-09T11:11:09+00:00","breadcrumb":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/#primaryimage","url":"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/02\/beitragsbild_uebergewicht-diabetes.jpg","contentUrl":"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/02\/beitragsbild_uebergewicht-diabetes.jpg","width":650,"height":450,"caption":"Bei rund 90 Prozent der Patient*innen mit Typ-2-Diabetes ist die Ursache ein starkes \u00dcbergewicht, auch als Adipositas bezeichnet."},{"@type":"BreadcrumbList","@id":"https:\/\/aktuelles.uni-frankfurt.de\/english\/blood-vessels-are-to-blame-why-obesity-leads-to-diabetes\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/aktuelles.uni-frankfurt.de\/"},{"@type":"ListItem","position":2,"name":"Blood vessels are to blame: why obesity leads to diabetes"}]},{"@type":"WebSite","@id":"https:\/\/aktuelles.uni-frankfurt.de\/#website","url":"https:\/\/aktuelles.uni-frankfurt.de\/","name":"Aktuelles aus der Goethe-Universit\u00e4t Frankfurt","description":"Aktuelles aus der Goethe-Universit\u00e4t | Neues aus Forschung, Lehre, Studium","publisher":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/aktuelles.uni-frankfurt.de\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/aktuelles.uni-frankfurt.de\/#organization","name":"Goethe University Frankfurt","url":"https:\/\/aktuelles.uni-frankfurt.de\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/aktuelles.uni-frankfurt.de\/#\/schema\/logo\/image\/","url":"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2022\/03\/800px-Goethe-Logo.png","contentUrl":"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2022\/03\/800px-Goethe-Logo.png","width":800,"height":436,"caption":"Goethe-Universit\u00e4t"},"image":{"@id":"https:\/\/aktuelles.uni-frankfurt.de\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/aktuelles.uni-frankfurt.de\/#\/schema\/person\/8e55ea338fb65d1ce87a91565d1f1739","name":"-","description":"Dieser Beitrag wurde von der Online-Redaktion ver\u00f6ffentlicht. Wenn der Beitrag von einem Gastautoren verfasst wurde, findet sich dieser Hinweis am Ende des jeweiligen Artikels.","sameAs":["http:\/\/aktuelles.uni-frankfurt.de\/autoren"],"url":"https:\/\/aktuelles.uni-frankfurt.de\/en\/author\/redaktion\/"}]}},"_links":{"self":[{"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/posts\/82486","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/comments?post=82486"}],"version-history":[{"count":0,"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/posts\/82486\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/media\/82485"}],"wp:attachment":[{"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/media?parent=82486"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/categories?post=82486"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/tags?post=82486"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/aktuelles.uni-frankfurt.de\/en\/wp-json\/wp\/v2\/post_folder?post=82486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}