{"id":83191,"date":"2025-03-21T13:32:50","date_gmt":"2025-03-21T12:32:50","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=83191"},"modified":"2025-03-21T13:32:50","modified_gmt":"2025-03-21T12:32:50","slug":"nursery-of-the-blood-how-stem-cells-calm-the-bodys-immune-response","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/nursery-of-the-blood-how-stem-cells-calm-the-bodys-immune-response\/","title":{"rendered":"Nursery of the Blood: How Stem Cells Calm the Body\u2019s Immune Response"},"content":{"rendered":"<p><em>International research team led by Professor Michael Rieger from Universit\u00e4tsmedizin Frankfurt analyzes blood stem cell developmental pathways<\/em><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/stammzellen.jpg\" alt=\"Blood stem cells, Copyright: Anusorn Nakdee\/Shutterstock.com\" class=\"wp-image-83188\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/stammzellen.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/stammzellen-300x208.jpg 300w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/stammzellen-500x346.jpg 500w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/stammzellen-18x12.jpg 18w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\">Blood stem cells \u2013 here an artist&#8217;s view \u2013 can suppress the immune response of defense cells.<\/figcaption><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Our blood consists of many cell types that develop through different stages from a precursor type \u2013 the blood stem cell. An international research team led by Universit\u00e4tsmedizin Frankfurt and Goethe University has now investigated the developmental pathways of blood cells in humans. The results yielded a surprise: Even stem cells possess surface proteins that enable them to suppress the activation of inflammatory and immune responses in the body. This finding is particularly relevant for stem cell transplants, applied for the treatment of e.g. leukemia.<\/strong><\/p>\n\n\n\n<p>Every second, an adult generates around five million new blood cells to replace aging or dying ones, making the blood system a highly regenerative organ. These new blood cells are formed in the bone marrow from unspecialized cells, known as blood stem cells. Through several intermediate stages, these stem cells develop into oxygen-transporting erythrocytes, blood-clotting platelets, and the large group of white blood cells which orchestrate the immune defense. This process, known as differentiation, must be precisely regulated to ensure a balanced production of mature blood cells across all cell types.<\/p>\n\n\n\n<figure class=\"wp-block-image alignleft size-full is-resized\"><img decoding=\"async\" width=\"450\" height=\"650\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/prof-dr-michael-rieger.jpg\" alt=\"Professor Michael Rieger, Universit\u00e4tsmedizin Frankfurt and Goethe University. Photo: Uwe Dettmar for Goethe University\" class=\"wp-image-83187\" style=\"width:210px\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/prof-dr-michael-rieger.jpg 450w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/prof-dr-michael-rieger-208x300.jpg 208w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/prof-dr-michael-rieger-346x500.jpg 346w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/prof-dr-michael-rieger-8x12.jpg 8w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption class=\"wp-element-caption\">Professor Michael Rieger, Universit\u00e4tsmedizin Frankfurt and Goethe University. Photo: Uwe Dettmar for Goethe University<\/figcaption><\/figure>\n\n\n\n<p>An international team of scientists from Universit\u00e4tsmedizin Frankfurt\/Goethe University, University of Gothenburg, and University Hospital Pamplona, led by Prof. Michael Rieger from Universit\u00e4tsmedizin Frankfurt\u2019s Department of Medicine II, has now molecularly decoded the differentiation pathways of human blood stem cells into all specialized blood cell types. Using state-of-the-art sequencing methods, the research team identified gene and protein expression patterns in more than 62,000 individual cells and analyzed the resulting data with high-performance computing.<\/p>\n\n\n\n<p>\u201cWe were able to gain an overview of the molecular processes in stem cells and discover new surface proteins that are crucial for the complex interaction between stem cells and their bone marrow environment,\u201d explains Rieger. \u201cThis provides us with detailed insights into what exactly the unique characteristics of a stem cell are and which genes regulate stem cell differentiation. This newly established technology in my lab will answer many unresolved questions in health research with extraordinary precision.\u201d<\/p>\n\n\n\n<figure class=\"wp-block-image alignright size-full is-resized\"><img decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/tessa-schmachtel.jpg\" alt=\"Tessa Schmachtel, Universit\u00e4tsmedizin Frankfurt and Goethe University. Photo: Uwe Dettmar for Goethe University\" class=\"wp-image-83186\" style=\"width:420px\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/tessa-schmachtel.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/tessa-schmachtel-300x208.jpg 300w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/tessa-schmachtel-500x346.jpg 500w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/03\/tessa-schmachtel-18x12.jpg 18w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\">Tessa Schmachtel, Universit\u00e4tsmedizin Frankfurt and Goethe University. Photo: Uwe Dettmar for Goethe University<\/figcaption><\/figure>\n\n\n\n<p>The researchers uncovered an unexpected finding: \u201cWe found a protein called PD-L2 on the surface of blood stem cells, which we know suppresses the immune response of our defense cells \u2013 the T cells \u2013 by preventing their activation and proliferation and inhibiting the release of inflammatory substances called cytokines,\u201d summarizes the study\u2019s first author, PhD student Tessa Schmachtel.<\/p>\n\n\n\n<p>PD-L2 likely serves to prevent immune-mediated damage, biologist Schmachtel explains. \u201cThis is particularly important for protecting stem cells from potential attacks by reactive T cells and likely plays a key role in stem cell transplantations with grafts from unrelated donors. PD-L2 could help to reduce the body\u2019s immune response against the transplanted stem cells.\u201d<\/p>\n\n\n\n<p>Rieger is convinced: \u201cGroundbreaking discoveries can only be made on the basis of close interdisciplinary collaboration between physicians, scientists, and bioinformaticians \u2013 as practiced at Universit\u00e4tsmedizin Frankfurt \u2013 and through the establishment of international networks.\u201d<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-background\" style=\"background-color:#eeeeee\"><strong>Publication:<\/strong> Hana Komic, Tessa Schmachtel, Catia Simoes, Marius K\u00fclp, Weijia Yu, Adrien Jolly, Malin S. Nilsson, Carmen Gonzalez, Felipe Prosper, Halvard Bonig, Bruno Paiva, Fredrik B. Thor\u00e9n, Michael A. Rieger: <strong><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-57096-y\" target=\"_blank\" rel=\"noreferrer noopener\">Continuous map of early hematopoietic stem cell differentiation across human lifetime<\/a><\/strong>. Nature Communications 16, Article number: 2287 (2025)<\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>International research team led by Professor Michael Rieger from Universit\u00e4tsmedizin Frankfurt analyzes blood stem cell developmental pathways Our blood consists of many cell types that develop through different stages from [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":83188,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[247],"post_folder":[],"class_list":["post-83191","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-medicine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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