{"id":84418,"date":"2025-06-17T10:27:48","date_gmt":"2025-06-17T08:27:48","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=84418"},"modified":"2025-06-17T10:27:49","modified_gmt":"2025-06-17T08:27:49","slug":"even-an-old-cluster-faces-entirely-new-challenges","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/even-an-old-cluster-faces-entirely-new-challenges\/","title":{"rendered":"\u201cEven an \u2018old\u2019 cluster faces entirely new challenges\u201d"},"content":{"rendered":"<p><strong>CPI spokesperson Prof. Stefanie Dimmeler on nearly 20 years in a continuously successful Cluster of Excellence and on new, exciting research questions in cardiovascular science<\/strong><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2022\/04\/Beitragsbild_Dimmeler.jpg\" alt=\"Stefanie Dimmeler, photo: Uwe Dettmar, Goethe University Frankfurt\" class=\"wp-image-57632\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2022\/04\/Beitragsbild_Dimmeler.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2022\/04\/Beitragsbild_Dimmeler-300x208.jpg 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\">Prof. Stefanie Dimmeler, photo: Uwe Dettmar, Goethe University Frankfurt<\/figcaption><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>UniReport: Congratulations, Professor Dimmeler. How does the success of CPI feel to you at this moment?<\/strong><\/p>\n\n\n\n<p><strong>Stefanie Dimmeler:<\/strong> I feel fantastic. Our success in the Excellence Strategy has been incredibly energizing \u2013 it makes my work even more enjoyable than before. The weekend after the decision, I was already working on new projects. Naturally, everyone was pretty nervous before the announcement, making it hard to focus on new ideas. You just didn\u2019t know if all the effort would pay off.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>How and where did you experience the decision? Was there a big celebration on May 22?<\/strong><\/p>\n\n\n\n<p>We were a bit superstitious and hadn\u2019t planned anything in advance. In Frankfurt, we gathered rather spontaneously in a small group. Whoever happened to be nearby joined in. Since we work at different locations, we\u2019ll be meeting soon in Bad Nauheim \u2013 our halfway point between Frankfurt and Giessen \u2013 for a proper celebration. But even the smaller gathering was lovely.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>CPI was already funded from 2006 to 2018 as the \u201cExcellence Cluster Cardio-Pulmonary System\u201d and has been supported again since 2019 as the Cardio-Pulmonary Institute (CPI). After such a comparatively long period of funding, does one enter the competition more confidently than a brand-new cluster project?<\/strong><\/p>\n\n\n\n<p>I was part of the first review in 2006, back then still as an early-career researcher. Of course, you build some routine over time, but that doesn\u2019t make it any less exciting. A new cluster certainly has to bring together many elements for the first time. But for a long-running project, the challenge consists of maintaining innovation at a high level. As they say in management: it\u2019s easier to go from 80 to 95 percent than from 95 to 99. That holds true for established clusters as well. CPI\u2019s fourth successful funding round is certainly exceptional. The challenge lies in constantly identifying new topics. You have to stay fresh and curious \u2013 not just keep doing what you\u2019ve always done. You have to ask: Where are we headed? That\u2019s a challenge \u2013 but a good one. It improves the quality of research because you\u2019re engaging directly with new questions. Research fields are also evolving, especially technologically \u2013 how can we build on that? In this sense, even an \u201cold\u201d cluster faces completely new challenges.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>CPI studies how the heart and lungs function, age, and become diseased \u2013 and how targeted treatments can be developed. Are you in global competition with other research? How do you maintain a unique edge?<\/strong><\/p>\n\n\n\n<p>There is certainly a great deal of international research in the cardio-pulmonary field, but CPI definitely has its unique strengths \u2013 for example, in pulmonary hypertension. We\u2019ve studied how the lung\u2019s blood vessels change under those conditions. Today, there are drugs \u2013 some developed with CPI involvement \u2013 that help treat the disease. People live longer thanks to these treatments, which introduces new challenges: a chronic stage of the disease. The same is true for atherosclerosis, which causes heart attacks \u2013 survival rates have dramatically improved. Now, we\u2019re turning our focus to aging: aging alone alters the heart and lung systems. So, we\u2019re asking: what promotes healthy aging and prevents entirely new heart and lung diseases? In aging, the heart and lungs interact strongly \u2013 the heart becomes stiff and less flexible, harming the lungs and creating a vicious cycle that contributes to aging. A good example is \u201cheart failure with preserved ejection fraction\u201d \u2013 not a problem of pumping, but of relaxation and expansion \u2013 which is one of the topics we are currently researching.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>How do you view collaboration with non-university partners like the Max Planck Institute? Is there something each side brings that the other doesn\u2019t?<\/strong><\/p>\n\n\n\n<p>We\u2019re definitely set up in a very synergistic way: with strong lung research in Giessen, strong vascular research in Frankfurt, and the Max Planck Institute, which brings outstanding basic research, excellent technical infrastructure, and solid funding. That was extremely helpful when the center was first founded. By now, we\u2019re complementary in our expertise \u2013 with the university hospitals contributing the clinical perspective. We really couldn\u2019t have designed it better.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Funding begins on January 1, 2026. Will there be overlap between the old and new funding periods?<\/strong><\/p>\n\n\n\n<p>We\u2019re still waiting to see how large the budget will be \u2013 the German Research Foundation (DFG) has hinted at possible cuts. Once the final budget is known, we\u2019ll plan CPI\u2019s future. Some of our programs will continue, especially our early-career programs, which have been very successful. We\u2019re also looking to internationalize these programs \u2013 hoping to attract postdocs from abroad, especially those who may find the U.S. less appealing right now. And in terms of professorships, we want to strengthen research into aging and its connection to the nervous system \u2013 these are important emerging fields, and we\u2019ll need even more expertise here.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Are there already connections or collaborations with SCALE, Goethe University&#8217;s second successful Cluster of Excellence, also at the research level?<\/strong><\/p>\n\n\n\n<p>Thematically, the two clusters are clearly distinct, but otherwise, there are many connections. Michaela M\u00fcller-McNicoll is a member of our cluster. Interestingly, CPI actually helped ensure she remained in Frankfurt \u2013 we used our Excellence funding at the time to support her professorship. There is a lot of mutual appreciation. I don\u2019t see any internal competition \u2013 it\u2019s more external. I was genuinely thrilled that SCALE was selected for funding. When the list of funded clusters was published online, my second glance immediately went to SCALE. Now both Frankfurt clusters need to explore how we can jointly support scientific fields to make the most of our funding \u2013 for the benefit of the entire university. That applies to Collaborative Research Centers and other research initiatives too: it\u2019s about attracting versatile researchers who can be applied in multiple contexts.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>What about the current collaborations within the RMU alliance?<\/strong><\/p>\n\n\n\n<p>We have excellent connections in cardiovascular research, especially since both Mainz and Frankfurt are sites of the German Center for Cardiovascular Research (DZHK), which closely links us. I&#8217;m also a partner in the Mainz \u201cCluster4Future\u201d, another fruitful collaboration.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-background\" style=\"background-color:#eeeeee\"><strong>SCALE: Subcellular Architecture of Life<\/strong><br>Cells are composed of billions of molecules, organized from individual components to large molecular complexes and organelles. While many single molecules are well characterized, it remains unclear how cellular architecture arises, functions, and how its components interact. Researchers in the SCALE cluster aim to uncover the cell\u2019s self-organization principles and create a high-resolution spatial and temporal simulation of cellular processes. This will improve our understanding of how cells actually function and how their various \u201cmachines\u201d cooperate. <br><br><strong>CPI: Cardio-Pulmonary Institute<\/strong><br>Cardiovascular and pulmonary diseases are among the leading causes of death worldwide. An aging population and emerging risk factors such as environmental pollutants and infections are making treatment increasingly complex. The Cardio-Pulmonary Institute (<a href=\"https:\/\/www.cpi-online.de\/\" target=\"_blank\" rel=\"noreferrer noopener\">CPI<\/a>) aims to pioneer new paths in medicine through innovative research. Under the motto \u201cPrecision Biology Drives Precision Medicine\u201d, CPI investigates how the heart and lungs function, age, and become diseased \u2013 and how they can be treated in a targeted manner. The institute follows an integrated approach, with scientists from diverse disciplines and clinics working together to develop therapies tailored to individual patients. Cutting-edge data analytics, clinical studies, and digital methods enable the rapid transfer of research into clinical practice. <\/p>","protected":false},"excerpt":{"rendered":"<p>CPI spokesperson Prof. Stefanie Dimmeler on nearly 20 years in a continuously successful Cluster of Excellence and on new, exciting research questions in cardiovascular science UniReport: Congratulations, Professor Dimmeler. How [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":57632,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[278,247,404],"post_folder":[],"class_list":["post-84418","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-interview-en","tag-medicine","tag-unireport-3-25"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cEven an \u2018old\u2019 cluster faces entirely new challenges\u201d | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/even-an-old-cluster-faces-entirely-new-challenges\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cEven an \u2018old\u2019 cluster faces entirely new challenges\u201d | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"CPI spokesperson Prof. Stefanie Dimmeler on nearly 20 years in a continuously successful Cluster of Excellence and on new, exciting research questions in cardiovascular science UniReport: Congratulations, Professor Dimmeler. 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