{"id":85932,"date":"2025-10-08T16:18:36","date_gmt":"2025-10-08T14:18:36","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=85932"},"modified":"2025-10-08T16:18:37","modified_gmt":"2025-10-08T14:18:37","slug":"how-blood-vessels-influence-brain-development","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/how-blood-vessels-influence-brain-development\/","title":{"rendered":"How Blood Vessels Influence Brain Development"},"content":{"rendered":"<p><em>New Koselleck Project at Goethe University Frankfurt: Neurobiologist Prof. Amparo Acker-Palmer Secures \u20ac1.25 million for Neurovascular Research<\/em><\/p>\n\n\n\n<p><strong>Blood vessels are more than just pathways for oxygen and nutrients; they also host communicative processes that guide brain development and sustain its function. These vascular-neuronal interfaces are at the core of new research led by Prof. Amparo Acker-Palmer, which will receive \u20ac1.25 million as a German Research Foundation (DFG) Koselleck Project.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image alignright size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"450\" height=\"650\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/amparo-acker-palmer-c-till-acker.jpg\" alt=\"Amparo Acker-Palmer \u00a9 Till Acker\" class=\"wp-image-85923\" style=\"width:270px\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/amparo-acker-palmer-c-till-acker.jpg 450w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/amparo-acker-palmer-c-till-acker-208x300.jpg 208w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/amparo-acker-palmer-c-till-acker-346x500.jpg 346w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/amparo-acker-palmer-c-till-acker-8x12.jpg 8w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption class=\"wp-element-caption\">Neuroscientist Amparo Acker-Palmer has secured a Koselleck project grant from the DFG. The project focuses on the connections between blood vessels and brain development. (\u00a9 Till Acker) <\/figcaption><\/figure>\n\n\n\n<p>Within blood vessels, specialized endothelial cells, which form the inner lining of all vessels, exchange signals with neurons and glial cells that decisively influence the formation of brain circuits and the development of brain architecture. Disruptions to this exchange can result in developmental disorders or neurodegeneration. In her newly approved, DFG-funded Koselleck Project, Prof. Amparo Acker-Palmer aims to explore the hidden functions of vascular-neuronal interfaces. Using cutting-edge imaging techniques, molecular profiling, and genetic models, she seeks to uncover where and how endothelial cells interact with neurons and other brain cells, as well as the principles by which these interactions shape brain connectivity and structure. A particular focus is on the cerebellum, which plays a key role in movement and certain cognitive processes, and on the role of blood vessels in brain folding, a process that diversifies and enhances brain functions. Defects in brain folding can lead to neurological disorders, including intellectual disabilities, epilepsy, and motor impairments.<\/p>\n\n\n\n<p>\u201cBy bringing together vascular biology and neurosciences, we are opening a new chapter in neurovascular research. Understanding how blood vessels regulate brain development is crucial not only for fundamental biology but also for developing new therapeutic strategies to address diseases caused by disrupted communication between vessels and neurons,\u201d says Professor Acker-Palmer, adding that the study has the potential to revolutionize neurovascular biology and unlock previously unknown therapies. Acker-Palmer holds the professorship for Molecular Neurobiology at Goethe University Frankfurt and is internationally recognized for her groundbreaking research on neurovascular communication. Her work has earned her several prestigious awards, including an ERC Advanced Grant.<\/p>\n\n\n\n<figure class=\"wp-block-image alignleft size-full is-resized\"><img decoding=\"async\" width=\"450\" height=\"650\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/blutgefaesse-c-marta-parilla-monge-jimena-redondo-nectali.jpg\" alt=\"3D reconstruction of blood vessels in the cerebellum of a mouse, rendered using artificial intelligence from iDISCO+.(Image: Marta Parilla Monge and Jimena Redondo Nectal\u00ed, AG Acker-Palmer) \" class=\"wp-image-85922\" style=\"width:270px\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/blutgefaesse-c-marta-parilla-monge-jimena-redondo-nectali.jpg 450w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/blutgefaesse-c-marta-parilla-monge-jimena-redondo-nectali-208x300.jpg 208w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/blutgefaesse-c-marta-parilla-monge-jimena-redondo-nectali-346x500.jpg 346w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2025\/10\/blutgefaesse-c-marta-parilla-monge-jimena-redondo-nectali-8x12.jpg 8w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption class=\"wp-element-caption\">3D reconstruction of blood vessels in the cerebellum of a mouse, rendered using artificial intelligence from iDISCO+.(Image: Marta Parilla Monge and Jimena Redondo Nectal\u00ed, AG Acker-Palmer) <\/figcaption><\/figure>\n\n\n\n<p>Acker-Palmer\u2019s lab is distinguished by its collaborative and interdisciplinary approach, bringing together vascular biologists and neuroscientists to ensure seamless knowledge exchange, innovation, and discovery. According to the neurobiologist, this creates an ideal environment for tackling the ambitious project. The project aligns well with the overarching goals of the German Research Foundation\u2019s (DFG) Koselleck Program, which aims to support visionary, high-risk research with the potential to open entirely new scientific fields.<\/p>\n\n\n\n<p>The Reinhart Koselleck funding line, awarded since 2008, is named after Reinhart Koselleck (1923\u20132006), one of the most important German historians of the 20th century and a co-founder of modern social history. Reinhart Koselleck Projects are awarded to \u201cresearchers distinguished by outstanding scientific achievements.\u201d The prerequisites for approval are particularly innovative research approaches and a certain degree of risk.<\/p>","protected":false},"excerpt":{"rendered":"<p>New Koselleck Project at Goethe University Frankfurt: Neurobiologist Prof. Amparo Acker-Palmer Secures \u20ac1.25 million for Neurovascular Research Blood vessels are more than just pathways for oxygen and nutrients; they also [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":85924,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[247],"post_folder":[],"class_list":["post-85932","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-medicine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How Blood Vessels Influence Brain Development | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/how-blood-vessels-influence-brain-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How Blood Vessels Influence Brain Development | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"New Koselleck Project at Goethe University Frankfurt: Neurobiologist Prof. Amparo Acker-Palmer Secures \u20ac1.25 million for Neurovascular Research Blood vessels are more than just pathways for oxygen and nutrients; 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