{"id":87632,"date":"2026-03-06T09:54:07","date_gmt":"2026-03-06T08:54:07","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=87632"},"modified":"2026-03-06T09:54:08","modified_gmt":"2026-03-06T08:54:08","slug":"contraception-without-hormones-goethe-university-researches-alternatives-to-the-pill","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/contraception-without-hormones-goethe-university-researches-alternatives-to-the-pill\/","title":{"rendered":"Contraception without hormones: Goethe University researches alternatives to \u201cthe pill\u201d"},"content":{"rendered":"<p><em>German Federal Ministry of Research funds PREVENT project in Frankfurt, Bonn and Munich with \u20ac3 million <\/em><strong><em><\/em><\/strong><\/p>\n\n\n\n<p><strong>The \u201cpill\u201d was once hailed as medical revolution, later it became the most widely used form of contraceptive.<\/strong> <strong>In recent years, however, hormonal contraceptives have increasingly come under critical scrutiny due to potential side effects and long-term health concerns<\/strong><strong>. A research team at Goethe University and its collaboration partners at University Hospital Bonn and Ludwig Maximilian University, Munich, has now launched the PREVENT research project. The initiative aims to develop innovative, non-hormonal contraceptives for both women and men. PREVENT is being funded by the German Federal Ministry of Research until 2029 with \u20ac3 million.<\/strong><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/03\/beitrag-Blister_Contraceptive_Pills_c_AI_GoetheUniversity-650x450-1.jpg\" alt=\"\" class=\"wp-image-87630\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/03\/beitrag-Blister_Contraceptive_Pills_c_AI_GoetheUniversity-650x450-1.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/03\/beitrag-Blister_Contraceptive_Pills_c_AI_GoetheUniversity-650x450-1-300x208.jpg 300w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/03\/beitrag-Blister_Contraceptive_Pills_c_AI_GoetheUniversity-650x450-1-500x346.jpg 500w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/03\/beitrag-Blister_Contraceptive_Pills_c_AI_GoetheUniversity-650x450-1-18x12.jpg 18w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\">Finding non-hormonal alternatives to the birth control pill is the research goal of the PREVENT project by Goethe University, University Hospital Bonn (UKB), and LMU Munich. Photo: Markus Bernards\/AI for Goethe University Frankfurt<\/figcaption><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>In the 1970s, the contraceptive pill was the most frequently used method of contraception in Western countries; in Germany, for example, one in three women used \u201cthe pill.\u201d It is safe and reliable, covered by (most) health insurances, and \u2013 particularly in the 1960s and 1970s \u2013 was also regarded as an instrument of female self-determination.<\/p>\n\n\n\n<p>Over time, however, a number of side effects associated with hormonal contraceptive methods became apparent, from nausea, weight gain, and breast tenderness to more serious risks such as high blood pressure, liver dysfunction, and thrombosis. Some medications, such as certain antibiotics or St. John\u2019s wort products, can reduce the effectiveness of the pill.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">The pill is increasingly rejected<\/h2>\n\n\n\n<p>Although side effects occur comparatively rarely, concerns about the risks have contributed to a declining acceptance of the pill. According to recent surveys by the German Federal Centre for Health Education, since 2023 fewer women and couples have been using the pill for contraception; among younger adults in particular, the condom has replaced the pill as the number one contraceptive method.<\/p>\n\n\n\n<p>A research team led by Dr. Claudia Tredup and Prof. Stefan Knapp from the Institute of Pharmaceutical Chemistry at Goethe University Frankfurt, Prof. Daniel Merk from Ludwig Maximilian University of Munich, and Prof. Hubert Schorle from UKB, who is also a member of the Transdisciplinary Research Area (TRA) \u201cLife &amp; Health\u201d at the University of Bonn, and Prof. Jean-Pierre Allam, Head of Andrology at UKB, is now working to develop contraceptives with particularly few side effects that do not rely on hormonal mechanisms. To this end, they have launched the PREVENT project (\u201cPrecision Reproductive and Contraceptive Target Discovery Network\u201d) and secured three years of project funding from the German Federal Ministry of Research, Technology and Space.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Active substances for new contraceptive strategies<\/h2>\n\n\n\n<p>PREVENT project leader Dr. Claudia Tredup from the Institute of Pharmaceutical Chemistry at Goethe University Frankfurt explains: \u201cHormonal contraceptive methods such as the contraceptive pill interfere with the body\u2019s natural hormone cycle. In PREVENT, we are investigating for alternative non-hormonal approaches for both women and men in order to offer couples additional contraceptive options.\u201d<\/p>\n\n\n\n<p>The PREVENT team\u2019s research approach focuses on so-called small molecules that specifically block proteins found exclusively in sperm or egg cells. For example, small molecules could specifically target sperm, preventing sperm from reaching the egg cell. Tredup explains: \u201cSince contraceptives are administered to healthy individuals, they must not only be reliable and reversible, but also safe and highly tolerable.\u201d<\/p>\n\n\n\n<p>Given these complex requirements, the search for suitable active substances is highly demanding. The PREVENT team will therefore develop a drug discovery platform to establish technologies and tools for validating non-hormonal contraceptive concepts. Highly selective and effective compounds \u2013 so-called \u201cchemical probes\u201d \u2013 will enable the targeted testing of new contraceptive strategies and provide a solid foundation for preclinical and later clinical development.<\/p>\n\n\n\n<p>Biochemist Tredup adds: \u201cWe already know of a number of genes associated with infertility. Within the PREVENT team, we want to build the expertise needed to use the corresponding proteins as target structures for safe, non-hormonal contraceptive strategies.\u201d She is convinced that this is not just a classic pharmaceutical research project: \u201cWith PREVENT, we are also addressing key societal goals of reproductive self-determination and global health policy.\u201d<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-background\" style=\"background-color:#eeeeee\"><strong>Contact:<\/strong> <br>Dr. Claudia Tredup<br>Project Manager PREVENT<br>Institute for Pharmaceutical Chemistry<br>Goethe University Frankfurt, Germany<br>Tel. +49 (0)69 29401<br><a href=\"mailto:tredup@pharmchem.uni-frankfurt.de\">tredup@pharmchem.uni-frankfurt.de<\/a><br><a href=\"https:\/\/www.sgc-frankfurt.de\/Pages\/research.html\">www.sgc-frankfurt.de\/Pages\/research.html<\/a><br><\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>German Federal Ministry of Research funds PREVENT project in Frankfurt, Bonn and Munich with \u20ac3 million The \u201cpill\u201d was once hailed as medical revolution, later it became the most widely [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":87630,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[243,244,245],"post_folder":[],"class_list":["post-87632","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-biochemistry","tag-chemistry","tag-pharmacy"],"yoast_head":"<!-- This site is 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