{"id":87994,"date":"2026-04-14T13:36:03","date_gmt":"2026-04-14T11:36:03","guid":{"rendered":"https:\/\/aktuelles.uni-frankfurt.de\/?p=87994"},"modified":"2026-04-14T13:43:06","modified_gmt":"2026-04-14T11:43:06","slug":"a-strong-start-for-scale-rethinking-life-through-digital-twins","status":"publish","type":"post","link":"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/a-strong-start-for-scale-rethinking-life-through-digital-twins\/","title":{"rendered":"A Strong Start for SCALE: Rethinking Life Through Digital Twins"},"content":{"rendered":"<p><strong>From virtual patients to simulated embryos and intelligent chicks: the applications of digital twins are expanding rapidly. These possibilities were at the center of the 7th International Giersch Conference 2026, which also served as the kickoff event for the new Cluster of Excellence SCALE. Its central theme: \u201cTowards Digital Twins for Structural Cell Biology \u2013 Criteria, Chances, and Challenges.\u201d<\/strong><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/04\/beitragsbild-auftakt-exzellenzcluster-scale-unireport-1-26-c-anja-stoeriko.jpg\" alt=\"\" class=\"wp-image-87955\" style=\"width:650px;height:auto\" srcset=\"https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/04\/beitragsbild-auftakt-exzellenzcluster-scale-unireport-1-26-c-anja-stoeriko.jpg 650w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/04\/beitragsbild-auftakt-exzellenzcluster-scale-unireport-1-26-c-anja-stoeriko-300x208.jpg 300w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/04\/beitragsbild-auftakt-exzellenzcluster-scale-unireport-1-26-c-anja-stoeriko-500x346.jpg 500w, https:\/\/aktuelles.uni-frankfurt.de\/wp-content\/uploads\/2026\/04\/beitragsbild-auftakt-exzellenzcluster-scale-unireport-1-26-c-anja-stoeriko-18x12.jpg 18w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\">Samantha Wood (Indiana University Bloomington) uses a digital twin to study how chicks develop perception, social behavior, and intelligence in their environment.<br>Photo: Anja St\u00f6riko<\/figcaption><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The research alliance SCALE (SubCellular Architecture of LifE) has been part of the Excellence Strategy of the German federal and state governments since this year. Scientists from Goethe University Frankfurt, the Max Planck Institutes for Biophysics and Brain Research, Saarland University, Johannes Gutenberg University Mainz, and FIAS aim to uncover the principles of self-organization within cells and to understand how cellular architecture develops and then enables the many diverse functions of a cell. To gain deeper insights into these processes, the researchers will combine experimental data with theoretical approaches to create digital twins of cell segments. These computer-based models are designed to observe, analyze, and predict dynamic processes within cells. In the long term, they could help researchers influence \u2013 or even redesign \u2013 cell functions in targeted ways. High-performance computer simulations at FIAS are at the heart of this digital twin project.<\/p>\n\n\n\n<p>The four-day conference, supported by the German Research Foundation (DFG) and the Frankfurt-based Giersch Foundation, marked the official launch of the Cluster of Excellence. It brought together international experts in computational science, structural biology, and systems biology to discuss the challenges and opportunities of digital twins in cell biology. The program focused on new scientific approaches, interdisciplinary collaboration, the integration of artificial intelligence and diverse data types, as well as concepts for open science and the open exchange of research data \u2013 key goals of the SCALE consortium. Some 130 participants attended the presentations and discussions, including candidates for newly created group leader positions.<\/p>\n\n\n\n<p>SCALE spokesperson Michaela M\u00fcller-McNicoll opened the conference together with FIAS Fellow Sebastian Thallmair. In his welcome address, Goethe University\u2019s Vice President Bernhard Br\u00fcne described SCALE as a \u201cflagship initiative in a unique environment with outstanding partners.\u201d FIAS Director Jan W\u00f6rner highlighted the institute\u2019s new motto, \u201cbiologically inspired computation,\u201d which aligns closely with SCALE\u2019s objectives.<\/p>\n\n\n\n<p>Dagmar Iber from ETH Zurich opened the lecture series with a fascinating look at digital twins of the female hormonal cycle, lung development, and bladder cancer formation. Max Bonomi from the Institut Pasteur presented his vision of integrative structural biology in the age of artificial intelligence, showing how different scales and data types can be brought together.<\/p>\n\n\n\n<p>The following days explored the potential of digital twins across multiple levels of life: from individual molecules to cellular machines, membranes, and cell-to-cell communication in organs and neural systems, all the way to the development and health of entire organisms. Andrej Sali (University of California), Martin Beck (Max Planck Institute for Biophysics and SCALE spokesperson), and Jan Kosinski (EMBL) demonstrated how combining mathematical and structural biology models can simulate complex transport pathways through nuclear pores. Sacha van Albada (Forschungszentrum J\u00fclich) and Stephan Preibisch (HHMI Janelia) presented different approaches to developing digital twins of the brain. Loic Royer (Biohub) described how artificial intelligence and large language models such as ChatGPT are transforming image data analysis and enabling the creation of digital embryos. Marcel Schulz (German Centre for Cardiovascular Research\/Goethe University) and Annalisa Marsico (Helmholtz Munich) presented their work on modeling and simulating gene expression networks. Samantha Wood (Indiana University Bloomington) uses digital twins to study how intelligence emerges and how chicks develop perception and social behavior in artificial environments. Liesbet Geris (University of Li\u00e8ge) highlighted the potential of human digital twins in healthcare, presenting successful applications in intensive care, pacemaker monitoring, and medication management.<\/p>\n\n\n\n<p class=\"has-text-align-left\">In a lively panel discussion moderated by Michaela M\u00fcller-McNicoll, Loic Royer, Liesbet Geris, Sacha van Albada, Sebastian Thallmair, and Stephan Preibisch explored where a simulation ends and a digital twin begins. Together with the audience, they discussed both the challenges that still need to be overcome and the opportunities that lie ahead. In addition to the invited talks, participants also presented their own research in short talks and poster sessions, further enriching the exchange on the criteria, opportunities, and challenges of structural cell biology. <\/p>\n\n\n\n<p class=\"has-text-align-right\">Anja St\u00f6riko\/FIAS, Michaela M\u00fcller-McNicoll\/SCALE<\/p>","protected":false},"excerpt":{"rendered":"<p>From virtual patients to simulated embryos and intelligent chicks: the applications of digital twins are expanding rapidly. These possibilities were at the center of the 7th International Giersch Conference 2026, [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":87955,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[126,254],"tags":[246,303,424],"post_folder":[],"class_list":["post-87994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english","category-research","tag-biological-sciences","tag-scale","tag-unireport-1-26"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A Strong Start for SCALE: Rethinking Life Through Digital Twins | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aktuelles.uni-frankfurt.de\/en\/english\/a-strong-start-for-scale-rethinking-life-through-digital-twins\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Strong Start for SCALE: Rethinking Life Through Digital Twins | Aktuelles aus der Goethe-Universit\u00e4t Frankfurt\" \/>\n<meta property=\"og:description\" content=\"From virtual patients to simulated embryos and intelligent chicks: the applications of digital twins are expanding rapidly. 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