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Perspective Lecture in Oncology – Targeting the tumour stroma to limit breast cancer metastasis
Mittwoch, 4. Dezember 2019, 18:00 bis 20:00
Vortrag von Prof. Dr. Clare Isacke, Team Leader – Breast Cancer Now Research Centre, Institute of Cancer Research, London, UK
Title of talk: „Targeting the tumour stroma to limit breast cancer metastasis“
Abstract: The Molecular Cell Biology Team seeks to identify strategies to effectively target key tumour-environment crosstalk pathways to limit metastatic relapse and enhance the efficacy of tumour targeting agents. Cancer-associated fibroblasts (CAFs) and activated pericytes participate in tumour development not only by their impact on cancer cells via paracrine signalling and the deposition of a neoplastic extracellular matrix, but also by their influence on other stromal populations – particularly in promoting a immunosuppressive, pro-tumour microenvironment. The presentation will address our current research in (a) assessing the efficacy of targeting CAF subpopulations to reduce breast cancer metastatic colonisation, (b) the mechanisms by which CAF-immune cell crosstalk influences tumour growth and response to therapy, and (c) the role of therapy-induced stromal damage in promoting metastatic relapse.